sarsoo/nanotech-coursework
1
0
Fork 0
Code Issues Pull Requests Packages Projects Releases Wiki Activity

added to part 2

Browse Source
This commit is contained in:
aj 2019-11-15 18:17:08 +00:00
parent b6d3c8e69c
commit 41bd17b625
5 changed files with 387 additions and 10 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

125
Taxol.svg Normal file
View File

@ -0,0 +1,125 @@
<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<svg xmlns:svg="http://www.w3.org/2000/svg" xmlns="http://www.w3.org/2000/svg" version="1.0" width="430" height="290.67999" viewBox="0 0 1730.283 1155.963" xml:space="preserve">
<g transform="matrix(0.9326549,0,0,0.932655,60.358709,53.489317)">
<polygon points="1367.002,587.998 1370.996,589.502 1371.494,594.502 1270.996,695.498 1267.5,687.5 1367.002,587.998" />
<polygon points="1367.002,447.5 1370.996,445.503 1375,448.003 1375,587.5 1370.996,589.502 1367.002,587.998 1367.002,447.5" />
<polygon points="1267.5,348.003 1270.996,340 1366.494,435.503 1370.996,445.503 1367.002,447.5 1267.5,348.003" />
<polygon points="1127.002,348.003 1125.498,343.999 1127.998,340 1270.996,340 1267.5,348.003 1127.002,348.003" />
<polygon points="879.497,649.502 870.996,652.998 890,510 893.994,508.501 897.5,511.001 879.497,649.502" />
<polygon points="990,734.004 988.994,743.496 870.996,652.998 879.497,649.502 990,734.004" />
<polygon points="1118.994,680.996 1122.5,683.496 1115.498,690.996 988.994,743.496 990,734.004 1118.994,680.996" />
<polygon points="1134.502,541.001 1138.496,539.502 1142.002,543.999 1127.002,680 1122.5,683.496 1118.994,680.996 1134.502,541.001" />
<polygon points="1026.494,458.003 1027.002,453.003 1032.998,452.5 1137.998,533.999 1138.496,539.502 1134.502,541.001 1026.494,458.003" />
<polygon points="897.5,511.001 893.994,508.501 894.502,503.999 1024.502,450 1027.002,453.003 1026.494,458.003 897.5,511.001" />
<rect width="8.0810003" height="113.848" x="966.45801" y="447.827" transform="matrix(0.3722,0.9281,-0.9281,0.3722,1077.7365,-583.8904)" />
<polygon points="1120.498,343.501 1125.498,343.999 1127.002,348.003 1032.998,452.5 1027.002,453.003 1024.502,450 1120.498,343.501" />
<polygon points="1267.5,687.5 1270.996,695.498 1125.996,687.998 1122.5,683.496 1127.002,680 1267.5,687.5" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1027.001,252.0015)" />
<polygon points="1073.994,265.503 1100.996,253.003 1127.998,340 1125.498,343.999 1120.498,343.501 1073.994,265.503" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1284.501,250.5005)" />
<rect width="8.0769997" height="96.848999" x="1269.707" y="250.828" transform="matrix(-0.9286,-0.3712,0.3712,-0.9286,2345.4165,1049.9187)" />
<rect width="8.0769997" height="96.848999" x="1293.71" y="260.828" transform="matrix(-0.9286,-0.3712,0.3712,-0.9286,2387.9978,1078.1141)" />
<polygon points="1495.996,657.002 1495.996,661.504 1492.5,664.502 1371.494,594.502 1370.996,589.502 1375,587.5 1495.996,657.002" />
<polygon points="1616.494,587.5 1620.498,589.502 1618.496,595.498 1501.494,662.998 1495.996,661.504 1495.996,657.002 1616.494,587.5" />
<polygon points="1616.494,448.003 1624.502,443.501 1624.502,588.496 1620.498,589.502 1616.494,587.5 1616.494,448.003" />
<polygon points="1495.996,378.501 1495.996,373.501 1500,371.499 1624.502,443.501 1616.494,448.003 1495.996,378.501" />
<polygon points="1375,448.003 1370.996,445.503 1375.498,438.501 1491.494,371.499 1495.996,373.501 1495.996,378.501 1375,448.003" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1652.498,753.4922)" />
<polygon points="1578.496,775.498 1556.494,797.5 1492.5,664.502 1495.996,661.504 1501.494,662.998 1578.496,775.498" />
<polygon points="1647.002,735.996 1650.996,742.998 1556.494,797.5 1578.496,775.498 1647.002,735.996" />
<polygon points="1618.496,595.498 1620.498,589.502 1624.502,588.496 1682.002,666.504 1655.996,681.504 1618.496,595.498" />
<polygon points="1222.998,422.5 1225.996,425 1229.502,427.5 1145.996,536.499 1138.496,539.502 1137.998,533.999 1222.998,422.5" />
<polygon points="1282.002,553.999 1281.494,558.003 1280.996,562.002 1142.002,543.999 1138.496,539.502 1145.996,536.499 1282.002,553.999" />
<polygon points="1355.996,301.499 1370.996,301.499 1385.996,301.499 1375.498,438.501 1370.996,445.503 1366.494,435.503 1355.996,301.499" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z M 85.742188,0 L 85.742188,-71.582031 L 95.214844,-71.582031 L 95.214844,-42.1875 L 132.42188,-42.1875 L 132.42188,-71.582031 L 141.89453,-71.582031 L 141.89453,0 L 132.42188,0 L 132.42188,-33.740234 L 95.214844,-33.740234 L 95.214844,0 L 85.742188,0 z" transform="translate(1455.9912,269.0054)" />
<polygon points="1480.996,281.499 1510.996,281.499 1500,371.499 1495.996,373.501 1491.494,371.499 1480.996,281.499" />
<path d="M 8.0078125,0 L 8.0078125,-71.582031 L 17.480469,-71.582031 L 17.480469,-42.1875 L 54.6875,-42.1875 L 54.6875,-71.582031 L 64.160156,-71.582031 L 64.160156,0 L 54.6875,0 L 54.6875,-33.740234 L 17.480469,-33.740234 L 17.480469,0 L 8.0078125,0 z" transform="translate(1334.998,772.499)" />
<polygon points="1385.996,689.502 1355.996,689.502 1357.002,681.504 1385,681.504 1385.996,689.502" />
<polygon points="1382.998,665.996 1359.502,665.996 1360.498,657.998 1381.494,657.998 1382.998,665.996" />
<polygon points="1379.502,642.002 1362.5,642.002 1363.994,634.004 1378.496,634.004 1379.502,642.002" />
<polygon points="1375.996,617.998 1365.996,617.998 1367.002,610 1375,610 1375.996,617.998" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1418.4912,839.999)" />
<polygon points="1485,760.996 1455.996,752.998 1458.994,745.498 1485.996,752.5 1485,760.996" />
<polygon points="1487.5,737.002 1465,730.996 1467.998,723.496 1488.496,729.004 1487.5,737.002" />
<polygon points="1490.498,713.496 1474.502,709.502 1477.5,702.002 1491.494,705.498 1490.498,713.496" />
<polygon points="1493.496,690 1483.496,687.5 1486.494,680 1494.502,682.002 1493.496,690" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1229.501,874.502)" />
<polygon points="1284.502,790 1254.502,790 1255.498,782.002 1282.998,782.002 1284.502,790" />
<polygon points="1280.996,766.504 1257.5,766.504 1258.496,758.496 1280,758.496 1280.996,766.504" />
<polygon points="1277.5,742.998 1260.996,742.998 1262.002,735 1276.494,735 1277.5,742.998" />
<polygon points="1274.502,719.502 1263.994,719.502 1265.498,711.504 1273.496,711.504 1274.502,719.502" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z M 85.742188,0 L 85.742188,-71.582031 L 95.214844,-71.582031 L 95.214844,-42.1875 L 132.42188,-42.1875 L 132.42188,-71.582031 L 141.89453,-71.582031 L 141.89453,0 L 132.42188,0 L 132.42188,-33.740234 L 95.214844,-33.740234 L 95.214844,0 L 85.742188,0 z" transform="translate(1045.5,862.002)" />
<polygon points="1111.494,782.5 1082.5,775 1115.498,690.996 1122.5,683.496 1125.996,687.998 1111.494,782.5" />
<polygon points="925,217.002 920.498,208.999 1019.502,208.999 1019.502,217.002 925,217.002" />
<polygon points="1199.502,964.502 1195,956.504 1240,878.496 1247.002,882.5 1199.502,964.502" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1228.999,1123.4922)" />
<rect width="8.066" height="104.193" x="1226.714" y="940.40302" transform="matrix(0.8681,-0.4964,0.4964,0.8681,-330.3339,741.8591)" />
<rect width="8.066" height="103.943" x="1204.463" y="953.526" transform="matrix(0.8681,-0.4964,0.4964,0.8681,-339.7211,732.5282)" />
<polygon points="1055.996,964.502 1053.994,960.498 1055.996,956.504 1195,956.504 1199.502,964.502 1055.996,964.502" />
<polygon points="979.502,839.502 983.994,831.504 1055.996,956.504 1053.994,960.498 1048.994,960.498 979.502,839.502" />
<polygon points="963.496,863.496 970.498,859.502 1027.5,958.496 1020.498,962.5 963.496,863.496" />
<polygon points="840,839.502 835.498,831.504 983.994,831.504 979.502,839.502 840,839.502" />
<polygon points="770.498,960.498 760.996,960.498 835.498,831.504 840,839.502 770.498,960.498" />
<polygon points="798.999,962.5 791.997,958.496 849.497,859.502 855.996,863.496 798.999,962.5" />
<polygon points="840,1080.996 835.498,1089.004 760.996,960.498 770.498,960.498 840,1080.996" />
<polygon points="979.502,1080.996 983.994,1089.004 835.498,1089.004 840,1080.996 979.502,1080.996" />
<rect width="114.502" height="7.9980001" x="852.5" y="1055" />
<polygon points="1048.994,960.498 1053.994,960.498 1055.996,964.502 983.994,1089.004 979.502,1080.996 1048.994,960.498" />
<polygon points="777.998,423.999 780,421.001 782.5,418.003 894.502,503.999 893.994,508.501 890,510 777.998,423.999" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(710.5005,762.002)" />
<polygon points="796.997,713.496 781.997,687.5 789.497,684.502 803.496,708.496 796.997,713.496" />
<polygon points="815.996,699.004 803.999,678.496 811.499,675.498 821.997,694.004 815.996,699.004" />
<polygon points="834.497,684.502 826.499,669.502 833.496,666.504 840.996,679.502 834.497,684.502" />
<polygon points="853.496,669.502 848.496,660.498 855.996,657.5 860,664.502 853.496,669.502" />
<polygon points="626.499,655.996 626.499,646.504 711.499,695.996 707.5,702.998 626.499,655.996" />
<polygon points="501.997,727.5 501.997,718.496 626.499,646.504 626.499,655.996 501.997,727.5" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(586.4995,547.0015)" />
<rect width="8.0030003" height="99.501999" x="609.49701" y="559.50201" />
<rect width="7.9980001" height="99.501999" x="635" y="559.50201" />
<polygon points="377.5,655.996 377.5,646.504 501.997,718.496 501.997,727.5 377.5,655.996" />
<polygon points="257.5,725.498 253.496,722.998 253.496,718.496 377.5,646.504 377.5,655.996 257.5,725.498" />
<polygon points="128.496,655.498 128.496,646.504 253.496,718.496 253.496,722.998 249.497,725.498 128.496,655.498" />
<polygon points="7.998,725.498 0,720.996 128.496,646.504 128.496,655.498 7.998,725.498" />
<rect width="8.0629997" height="113.805" x="75.216003" y="652.599" transform="matrix(0.4959,0.8684,-0.8684,0.4959,656.045,288.8138)" />
<polygon points="7.998,865 0,869.502 0,720.996 7.998,725.498 7.998,865" />
<polygon points="128.496,934.502 128.496,943.496 0,869.502 7.998,865 128.496,934.502" />
<rect width="8.0629997" height="113.805" x="75.216003" y="823.59497" transform="matrix(0.4959,-0.8684,0.8684,0.4959,-724.6393,512.6364)" />
<polygon points="249.497,865 257.5,869.502 128.496,943.496 128.496,934.502 249.497,865" />
<polygon points="249.497,725.498 253.496,722.998 257.5,725.498 257.5,869.502 249.497,865 249.497,725.498" />
<rect width="8.0030003" height="114.004" x="223.496" y="737.99799" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z M 85.742188,0 L 85.742188,-71.582031 L 95.214844,-71.582031 L 95.214844,-42.1875 L 132.42188,-42.1875 L 132.42188,-71.582031 L 141.89453,-71.582031 L 141.89453,0 L 132.42188,0 L 132.42188,-33.740234 L 95.214844,-33.740234 L 95.214844,0 L 85.742188,0 z" transform="translate(462.0015,905.501)" />
<polygon points="516.997,820.996 486.997,820.996 487.998,812.998 515.996,812.998 516.997,820.996" />
<polygon points="513.496,797.998 490.498,797.998 491.499,790 512.5,790 513.496,797.998" />
<polygon points="510.498,774.502 493.496,774.502 494.497,766.504 509.497,766.504 510.498,774.502" />
<polygon points="506.997,750.996 496.997,750.996 497.998,742.998 505.996,742.998 506.997,750.996" />
<path d="M 7.6171875,0 L 7.6171875,-71.582031 L 17.333984,-71.582031 L 54.931641,-15.380859 L 54.931641,-71.582031 L 64.013672,-71.582031 L 64.013672,0 L 54.296875,0 L 16.699219,-56.25 L 16.699219,0 L 7.6171875,0 z M 80.273438,0 L 80.273438,-71.582031 L 89.746094,-71.582031 L 89.746094,-42.1875 L 126.95313,-42.1875 L 126.95313,-71.582031 L 136.42578,-71.582031 L 136.42578,0 L 126.95313,0 L 126.95313,-33.740234 L 89.746094,-33.740234 L 89.746094,0 L 80.273438,0 z" transform="translate(342.4985,547.0015)" />
<polygon points="362.5,558.999 392.5,558.999 391.499,567.002 363.999,567.002 362.5,558.999" />
<polygon points="365.996,580.498 389.497,580.498 387.998,588.496 366.997,588.496 365.996,580.498" />
<polygon points="368.999,602.002 385.996,602.002 385,610 370.498,610 368.999,602.002" />
<polygon points="372.5,623.496 382.998,623.496 381.499,631.504 373.496,631.504 372.5,623.496" />
<polygon points="249.497,438.501 257.5,433.999 335,478.501 330.996,485.503 249.497,438.501" />
<polygon points="249.497,295 253.496,292.5 257.5,295 257.5,433.999 249.497,438.501 249.497,295" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(89.5015,547.0015)" />
<rect width="8.059" height="106.173" x="216.468" y="416.91299" transform="matrix(0.4962,0.8682,-0.8682,0.4962,519.1427,45.3463)" />
<polygon points="163.496,477.5 159.497,471.001 251.499,417.5 255.498,424.502 163.496,477.5" />
<polygon points="373.999,218.501 381.997,223.003 257.5,295 253.496,292.5 253.496,288.003 373.999,218.501" />
<polygon points="373.999,78.999 381.997,74.502 381.997,223.003 373.999,218.501 373.999,78.999" />
<rect width="7.9980001" height="114.004" x="347.99799" y="91.499001" />
<polygon points="253.496,8.999 253.496,0 381.997,74.502 373.999,78.999 253.496,8.999" />
<polygon points="132.5,78.999 124.497,74.502 253.496,0 253.496,8.999 132.5,78.999" />
<rect width="8.059" height="114.237" x="199.96899" y="5.882" transform="matrix(0.4962,0.8682,-0.8682,0.4962,157.4713,-145.3738)" />
<polygon points="132.5,218.501 124.497,223.003 124.497,74.502 132.5,78.999 132.5,218.501" />
<polygon points="253.496,288.003 253.496,292.5 249.497,295 124.497,223.003 132.5,218.501 253.496,288.003" />
<rect width="8.0629997" height="114.237" x="199.967" y="176.881" transform="matrix(0.4959,-0.8684,0.8684,0.4959,-100.3671,295.0923)" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(810.9917,127.4985)" />
<rect width="8.059" height="100.591" x="886.21698" y="132.205" transform="matrix(-0.8682,0.4962,-0.4962,-0.8682,1753.7212,-100.7964)" />
<polygon points="883.994,128.003 890.996,123.999 940.996,211.001 934.502,215 883.994,128.003" />
<polygon points="854.497,338.999 850.996,337.002 847.5,335 920.498,208.999 925,217.002 854.497,338.999" />
<polygon points="1532.998,921.504 1527.998,929.502 1480.498,846.504 1487.5,842.5 1532.998,921.504" />
<path d="M 4.8339844,-34.863281 C 4.8339795,-46.744745 8.0240805,-56.046493 14.404297,-62.768555 C 20.784484,-69.49049 29.020153,-72.85149 39.111328,-72.851563 C 45.719355,-72.85149 51.676381,-71.272715 56.982422,-68.115234 C 62.288349,-64.957617 66.332941,-60.554952 69.116211,-54.907227 C 71.899342,-49.259391 73.290942,-42.854775 73.291016,-35.693359 C 73.290942,-28.434216 71.8261,-21.940082 68.896484,-16.210938 C 65.966731,-10.48176 61.816344,-6.1441996 56.445313,-3.1982422 C 51.074168,-0.25227839 45.279903,1.2207019 39.0625,1.2207031 C 32.324186,1.2207019 26.302057,-0.40690063 20.996094,-3.6621094 C 15.690088,-6.9173108 11.66991,-11.360666 8.9355469,-16.992188 C 6.2011657,-22.623675 4.8339795,-28.580701 4.8339844,-34.863281 L 4.8339844,-34.863281 z M 14.599609,-34.716797 C 14.599595,-26.090469 16.918928,-19.295228 21.557617,-14.331055 C 26.196263,-9.3668526 32.014942,-6.8847587 39.013672,-6.8847656 C 46.142532,-6.8847587 52.010039,-9.3912667 56.616211,-14.404297 C 61.22227,-19.417298 63.525327,-26.529921 63.525391,-35.742188 C 63.525327,-41.568969 62.540628,-46.655227 60.571289,-51.000977 C 58.601829,-55.346624 55.720973,-58.715762 51.928711,-61.108398 C 48.136345,-63.500913 43.880164,-64.697201 39.160156,-64.697266 C 32.454395,-64.697201 26.684544,-62.394143 21.850586,-57.788086 C 17.016585,-53.181913 14.599595,-45.491491 14.599609,-34.716797 L 14.599609,-34.716797 z" transform="translate(1418.999,1089.0059)" />
<polygon points="1495.996,1019.004 1488.994,1015 1542.002,923.496 1548.994,927.5 1495.996,1019.004" />
<polygon points="1473.994,1005.996 1467.002,1002.002 1519.502,910.498 1526.494,914.502 1473.994,1005.996" />
<polygon points="1673.994,921.504 1673.994,925.498 1673.994,929.502 1527.998,929.502 1532.998,921.504 1673.994,921.504" />
</g>
</svg>
Side by Side

After

Width:  |  Height:  |  Size: 32 KiB

202
coursework.lyx
View File

@ -216,7 +216,7 @@ status open
\begin_inset Graphics
filename WellBandStructure.png
lyxscale 40
width 60col%
width 50col%
\end_inset
@ -1422,7 +1422,7 @@ status open
\begin_inset Graphics
filename probability-plot.png
lyxscale 30
width 75col%
width 60col%
\end_inset
@ -1468,7 +1468,7 @@ status open
\begin_inset Graphics
filename probability-plot-with-n-2.png
lyxscale 30
width 75col%
width 60col%
\end_inset
@ -1613,7 +1613,7 @@ status open
\begin_inset Graphics
filename probability-plot-with-bounds.png
lyxscale 30
width 75col%
width 60col%
\end_inset
@ -1751,7 +1751,7 @@ Considering these two probabilities it is clear that it is more likely for
the electron to be found between 6nm and 8nm than between 2nm and 4nm across
the well.
This is as expected considering 6nm to 8nm places the interval towards
the center of the well.
the center of the 14.87nm well.
As the probability density function is a
\begin_inset Formula $\sin^{2}$
\end_inset
@ -1786,26 +1786,208 @@ Application of Nanomaterials
\begin_layout Standard
The use of albumin protein nanoparticlces has provided a new delivery method
for the highly effective chemotherapy drug, paclitaxel, in turn reducing
side effects caused by previous delivery schemes and increasing circulation
half life around the body.
side effects and toxicity caused by previous delivery schemes and increasing
circulation half life around the body.
\end_layout
\begin_layout Section
Paclitaxel
\end_layout
\begin_layout Section
Previous Delivery
\begin_layout Standard
Paclitaxel is a chemotherapy drug in the taxane family which function as
mitotic inhibitors.
This involves the suppression of mitosis or cell division which is effective
in treating cancer as constant cell mitosis is how cancer spreads throughout
the body.
\end_layout
\begin_layout Standard
While taxanes are an effective cancer treatment, their use has proved difficult
as they are not particularly soluble in water requiring a delivery vehicle
in order to allow intraveneous application.
\end_layout
\begin_layout Standard
\begin_inset Float figure
wide false
sideways false
status open
\begin_layout Plain Layout
\align center
\begin_inset Graphics
filename Taxol.svg
lyxscale 30
width 30col%
\end_inset
\end_layout
\begin_layout Plain Layout
\begin_inset Caption Standard
\begin_layout Plain Layout
Chemical structure for paclitaxel
\end_layout
\end_inset
\end_layout
\begin_layout Plain Layout
\end_layout
\end_inset
\end_layout
\begin_layout Section
Albumin
Previous Delivery Methods
\end_layout
\begin_layout Standard
As a result of the poor water solubility of taxanes and paclitaxel, a method
for delivering a solution was required.
Polyethoxylated castor oil (commercially known as Kolliphor EL, formerly
Cremophor EL [CrEL]) combined with dehydrated ethanol provides a suitable
formulation vehicle for many poorly water soluble and has been the standard
for many forms of commercially available paclitaxel such as Taxol.
\end_layout
\begin_layout Standard
While this solution has proved to be an effective delivery mechanism there
are significant side effects.
CrEL has been shown to cause severe hypersensitivity reactions and peripheral
neuropathy which are exacerbated by the high volumes of delivery agent
which must be coadministered with the active ingredient
\begin_inset CommandInset citation
LatexCommand cite
key "elsevier_sdoi_10_1016_S0959_8049_01_00171_X"
literal "false"
\end_inset
.
The use of CrEL also affects the behaviour of paclitaxel when administered,
manifesting as undesirable non-linear absorption, distribution, metabolism
and excretion behaviour
\begin_inset CommandInset citation
LatexCommand cite
key "proquest78006535"
literal "false"
\end_inset
, typically referred to as a drug's pharmacokinetic characteristics.
\end_layout
\begin_layout Section
Human Serum Albumin
\end_layout
\begin_layout Standard
Human serum albumin (HSA), sometimes referred to as blood albumin is the
most frequently found protein in the human body
\begin_inset CommandInset citation
LatexCommand cite
key "proquest1881262578"
literal "false"
\end_inset
and is part of the albumin family of proteins.
HSA is produced by the liver and performs important functions such as maintaini
ng oncotic pressure in the blood vessels, ensuring the right levels of fluids
are found between blood vessels and body tissues, and transporting hormones
and fatty acids around the body.
\end_layout
\begin_layout Standard
\begin_inset Float figure
wide false
sideways false
status open
\begin_layout Plain Layout
\align center
\begin_inset Graphics
filename hsa.jpg
lyxscale 30
width 40col%
\end_inset
\end_layout
\begin_layout Plain Layout
\begin_inset Caption Standard
\begin_layout Plain Layout
Crystal structure of human serum albumin with binding sites annotated
\begin_inset CommandInset citation
LatexCommand cite
key "BARBOSA2014345"
literal "false"
\end_inset
\end_layout
\end_inset
\end_layout
\begin_layout Plain Layout
\end_layout
\end_inset
\end_layout
\begin_layout Standard
Importantly for the application of drug delivery HSA along with the rest
of the albumin proteins are water soluble and HSA effectively binds with
both hydrophobic and hydrophilic chemicals
\begin_inset CommandInset citation
LatexCommand cite
key "proquest1881262578"
literal "false"
\end_inset
.
Critically HSA has been shown to be nontoxic, non-immunogenic (provokes
little response from the immune system), biocompatible and biodegradable
\begin_inset CommandInset citation
LatexCommand cite
key "wos000301045400002"
literal "false"
\end_inset
providing many advantages over Cremophor EL delivery.
\end_layout
\begin_layout Section
NAB-Paclitaxel
\end_layout
\begin_layout Standard
Word Count:
\end_layout
\begin_layout Standard
\begin_inset Newpage pagebreak
\end_inset

BIN
coursework.pdf
View File

Binary file not shown.

BIN
hsa.jpg Normal file
View File

Binary file not shown.
Side by Side

After

Width:  |  Height:  |  Size: 52 KiB

70
references.bib
View File

@ -15,6 +15,7 @@ year = "2014-11"
@misc{new_semiconductor_materials_archive,
title={NSM Archive - Physical Properties of Semiconductors},
author={IoffeInstitute},
url={http://matprop.ru/},
journal={New Semiconductor Materials Archive},
publisher={Ioffe Institute}
@ -78,5 +79,74 @@ volume = "55",
year = "1989-08-14",
}
@article{elsevier_sdoi_10_1016_S0959_8049_01_00171_X,
author = "Gelderblom, H and Verweij, J and Nooter, K and Sparreboom, A",
issn = "0959-8049",
journal = "European Journal of Cancer",
keywords = "Cremophor El ; Formulation Vehicles ; Paclitaxel ; Pharmacokinetics ; Pharmacodynamics ; Medicine",
language = "eng",
number = "13",
pages = "1590,1598",
publisher = "Elsevier Ltd",
title = "Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation",
volume = "37",
year = "2001-09",
}
@article{proquest78006535,
author = "Sparreboom, A and van Tellingen, O and Nooijen, W J and Beijnen, J H",
issn = "0008-5472",
journal = "Cancer research",
keywords = "Animals–Pharmacokinetics ; Antineoplastic Agents, Phytogenic–Analogs & Derivatives ; Chromatography, High Pressure Liquid–Pharmacokinetics ; Dose-Response Relationship, Drug–Pharmacokinetics ; Female–Pharmacokinetics ; Glycerol–Pharmacokinetics ; Humans–Pharmacokinetics ; Mice–Pharmacokinetics ; Paclitaxel–Pharmacokinetics ; Pharmaceutical Vehicles–Pharmacokinetics ; Solvents–Pharmacokinetics ; Antineoplastic Agents, Phytogenic ; Pharmaceutical Vehicles ; Solvents ; Cremophor El ; Paclitaxel ; Glycerol",
language = "eng",
number = "9",
pages = "2112,2115",
title = "Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL.",
url = "http://search.proquest.com/docview/78006535/",
volume = "56",
year = "1996-05-01",
}
@article{proquest1881262578,
author = "Lomis, Nikita and Westfall, Susan and Farahdel, Leila and Malhotra, Meenakshi and Shum-Tim, Dominique and Prakash, Satya",
issn = "2079-4991",
journal = "Nanomaterials (Basel, Switzerland)",
keywords = "Mcf-7 ; Cancer ; Human Serum Albumin ; Nanoparticles ; Paclitaxel",
language = "eng",
number = "6",
title = "Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization.",
url = "http://search.proquest.com/docview/1881262578/",
volume = "6",
year = "2016-06-15",
}
@article{wos000301045400002,
author = "Elzoghby, Ao and Samy, Wm and Elgindy, Na",
issn = "0168-3659",
journal = "Journal Of Controlled Release",
language = "English",
number = "2",
pages = "168,182",
publisher = "ELSEVIER SCIENCE BV",
title = "Albumin-based nanoparticles as potential controlled release drug delivery systems",
volume = "157",
year = "2012-01-30",
}
@incollection{BARBOSA2014345,
title = "Chapter 32 - Fibrillation and Polymorphism of Human Serum Albumin",
editor = "Vladimir N. Uversky and Yuri L. Lyubchenko",
booktitle = "Bio-nanoimaging",
publisher = "Academic Press",
address = "Boston",
pages = "345 - 362",
year = "2014",
isbn = "978-0-12-394431-3",
doi = "https://doi.org/10.1016/B978-0-12-394431-3.00032-8",
url = "http://www.sciencedirect.com/science/article/pii/B9780123944313000328",
author = "Silvia Barbosa and Pablo Taboada and Víctor Mosquera",
keywords = "human serum albumin, misfolded states, downhill polymerization, nucleation, lag phase, structural intermediates, curly fibrils, polymorphism, spherulites, biohybrid materials",
abstract = "Protein misfolding and self-assembly of disease-related and disease-unrelated proteins and peptides into highly ordered β-sheet-rich amyloid fibrils converts this self-assembly pathway in a ‘generic property’ of polypeptide chains. Hence, to gain a detailed knowledge about the underlying packing and fibrillation mechanisms of such a process the use of model proteins appears to be the key. Human serum albumin (HSA) appears to be an excellent candidate because it is highly abundant and plays fundamental biologic roles; it also displays a complex tertiary structure without any propensity to fibrillation in its native state. Thus, in this chapter, we first give a very brief summary of the main aspects of the origin of protein fibrillation. Subsequently, we describe how the various factor induce HSA fibrillation, and we also describe the possible aggregation pathways and the structure of the resulting fibrils."
}